Peripheral Arterial Disease is used to describe the impairment of blood flow to extremities as a result of atherosclerotic occlusive disease. Patients with vascular disease have a high risk of mortality, primarily from cardiovascular disease. D-dimer is a product of fibrin degradation by plasmin. Elevated levels of D-dimers are usually considered as marker of increased clotting activity, increased risk of severe atherosclerosis and increased risk of vascular complications.
Aims: To study the correlation of D-dimer with the severity of peripheral vascular disease.
Material and Methods: A prospective study was conducted in the General Surgery Department to study the correlation of D-dimer with peripheral arterial disease. Patients with ankle brachial index <0.9 were identified and investigated for D-dimer levels in their blood.
Statistical Analysis: Categorical variables were presented in number and percentage (%) and continuous variables were presented as mean ± SD and median. Normality of data was tested by Kolmogorov-Smirnov test. If the normality was rejected then non-parametric test was used.
Results: A total of 50 patients were included in the study. The study of the demographic details of patients showed increased severity of PAD with increasing age and a male preponderance. Smoking as a risk factor with severity of PAD and diabetes was found to be the most frequently associated co morbidity with PAD. However, no positive correlation could be found between D-dimer levels and co- morbidities, diabetes, hypertension, CAD, CVD and renal disease. D-dimer levels did not correlate with the severity of PAD.
Conclusion: A similar study needs to be done on a larger scale with a more sensitive quantitative estimation of D-dimer levels to yield statistically significant results correlating D- dimer levels with the severity of PAD.