Effect of topical nifedipine in treatment of chronic anal fissure
Author(s): Dr. Chanadrashekaraiah KC and Dr. Chinnabovi
Abstract: Chronic anal fissure is the most common cause of anal pain associated with internal anal sphincter hypertonia. Reduction of hypertonocity is a special treatment for fisssure healing. For this purpose chronic anal fissure were conventionally treated by anal dilatation or by lateral sphincterotomy. However, both of these methods may cause a degree of incontinence in some patients. The uptake of medical therapies that create a reversible chemical sphincterotomy has recently become widespread. The aim of this study is to assess the effectiveness of nifedipine in heling anal fissure, a calcium channel blocker that reduces sphincter pressure. An observational study conducted with 100 patients of chronic anal fissures treated with 0.3% nifedipine and 1.5% lignocaine. A net 52(52%) patients got there fissures healed with nifedipine. Remaining 48(48%) patients underwent surgery and there fissures healed with out complication. 4(4%) patients reported mild head ache with nifedipine use. Even though significant number of fissures heal with nifedipine recurrence is common. Another finding is low complication rate with nifedipine.