Vol. 3, Issue 4, Part C (2019)

Author(s): Dr. Sandeep Gupta, Dr. Surendra Beniwal, Dr. Shankar Jakhar and Dr. Jitendra Acharya

Abstract: Introduction: We have lot of studies regarding Ductal Carcinoma in Situ (DCIS) succeeding into Invasive Ductal Carcinoma (IDC) of the breast. Still, there is hardly any study on the coexistence of both and its clinical significance. The aim of this study is to evaluate the clinical and pathological parameters of synchronous DCIS and IDC to estimate the prognostic factors. Materials and Methods: Total 42 patients with a final diagnosis of synchronous DCIS and IDC diagnosed in 20015-18 were included in the study. Statistical analysis was done using SPSS software utilizing the appropriate analytical methods. Results: Majority of the patients in this study group presented with early breast cancer (64.3%).48% were Her2 subtype and 31% were triple negative. Grade 3 lesions were more common (57%). 81% of the IDC associated histology was Not Otherwise Specified (NOS) type. Recurrence was common in node positive disease (59.5%), those with lymphovascular emboli (59.5%) and perinodal spread (76%) on histopathological examination. Conclusion: Synchronous DCIS and IDC disease being appears to have a destructive nature compared to the course of IDC alone being. Prognostic factors linking to IDC appears to associate well with recurrence than that of the prognostic factors of DCIS module in such synchronous setting.