Vol. 4, Issue 2, Part D (2020)

Abstract: In autoimmune thyroiditis animal models, genetically determined immune defects have been suggestively linked to the breakdown of immunological self-tolerance that results in the presentation of host autoantigens and expansion of autoreactive lymphocyte clones. These immune and immune regulatory genes (i.e., CTLA-4 and others) are also involved. 100 consecutive patients with diagnosis of Hashimoto’s thyroiditis were included in this study. Detailed clinical history and physical examination of the patients was done. Suspected patients were subjected to thyroid function test, FNAC, USG neck. The diagnosis was confirmed with serology. 69 percent of patients (65 females: 4 males) presented with hypothyroidism. 1 patient with associated orbitopathy had subclinical hyperthyroidism. 10 patients presented in euthyroid state. Most of them had associated goiters and many of them had associated pathologies of MNG or malignancy in them. 10 patients had subclinical hypothyroidism.