Role of clarithromycin in reducing mastectomy induced acute inflammatory response
Author(s): Pankaja SS, Harish Kumar P and Girish Kumar NM
Abstract:Background: Surgery induces both inflammation and immunosuppression as part of systemic stress response. Based on the observation that administration of clarithromycin led to an attenuation of the mastectomy induced inflammatory response, we evaluated the anti-inflammatory effects of clarithromycin on mastectomy induced inflammatory response.
Methods: During a 18-month period, 60 patients who underwent modified radical mastectomy (MRM) were randomly allocated to one of the two study groups. In one group patients received oral clarithromycin (500mg) twice daily. Second group was control.
Results: Significant reduction in acute phase reactant, C-Reactive Protein (CRP), Median CRP values were significantly lesser on postoperative day 1 and 2 in the clarithromycin group.
Conclusions: In conclusion, clarithromycin has beneficial anti-inflammatory effect on surgery induced acute inflammatory response.