To evaluate the role of antibiotic prophylaxis in general surgery with the incidence of wound infection and in comparison with extended regimen antibiotics.
Methods: A prospective study of 150 patients were enrolled and operated upon electively which are divided into 2 groups. 100 patients were taking prophylactic antibiotics and 50 patients were on extended antibiotic regimen. Questionnaires concerning age, sex, type of surgery, complications and parameters of antibiotic prophylaxis (antibiotic choice, route, dose, timing of first dose and duration of prophylaxis) were completed.
Results: Patients with prophylactic antibiotic, 79% of patients underwent a clean surgical operation and 21% underwent a clean contaminated operation. Inguinal hernia and open cholecystectomy were the commonest operation in each category, 4% of this group developing wound infection, also we take comparison with 50 cases in which we use extended antibiotic regimen Laparoscopic cholecystectomy and Para umbilical hernia were the commonest operations in this category, 6% of this group developing wound infection Ampicillin and cefotaxime were the most frequently prescribed antibiotics (50%, 50% respectively). All the 100 patients were received the antibiotic on time.
Conclusions: This study found that the use of pre-operative prophylactic antibiotics does have a statistically significant effect on postoperative infection rates in surgical management.