Vol. 5, Issue 3, Part B (2021)

Author(s): Dr. Singhvi Inderchand and Dr. Avinash Kulkarni

Abstract: A number of observations by nineteenth-century physicians and investigators were critical to our current understanding of the pathogenesis, prevention, and treatment of surgical infections. In 1846, Ignaz Semmelweis, a Magyar physician, took a post at the Allgemein Krankenhaus in Vienna. He noticed that the mortality from puerperal ("childbed") fever was much higher in the teaching ward (1:11) than in the ward where patients were delivered by midwives (1:29). The patients were divided into two groups: Group A: Prophylaxis by systemic (intravenous) infiltration of the antibiotic. Group B: Prophylaxis by both systemic (intravenous) and intra-incisional infiltration of the antibiotic. The first patient was allocated to group A. The second patient to group B, the third one to group A and so on so forth till we achieved our desired number of subjects in both the groups. In Group 1, duration of surgery of >1hr were 3(5%), same as in group 2. The percentage duration of surgery >1 hr and <1 hr of in both the groups were Equal.(P=1.000). In Group 1, the mean preoperative TLC was 6838.00 ± 1700.00 and in Group 2 it was 7126.00 ± 1815.00.The mean preoperative TLC was comparable between the two groups (P>0.05).