Abstract: Background: Helicobacter pylori infection of the gallbladder has been shown to increase the precipitation of cholesterol to form stones. Also it has been shown that urease induced calcium precipitation by Helicobacter species may initiate gallstone formation. This has raised a question about the possible role of Helicobacter species in the aetiology of gallbladder diseases especially cholelithiasis. Owing to conflicting results on the topic in the studies presently available and more so, only a few studies being reported in Northern India regarding this aspect and additionally having discordant findings. Our study was conceptualized in the Southern India scenario.
Methods: During 18 months study period those diagnosed with calculous cholecystitis with USG, patients underwent Laparoscopic Cholecystectomy, the gall bladder specimen sent for histopathological examination for the presence of H. pylori and the mucosal changes associated with infection of the gallbladder with Helicobacter pylori.
Results: No statistical significance was seen between H. pylori and gender. Among those having H. pylori majority were females. (p=0.23). No statistical significance was seen between H. pylori and type of stone. Among those having H. pylori majority were pigmented type. (p=0.67) High statistical significance was seen between H. pylori and Inflammatory mononuclear infiltrate. P<0.01, High statistical significance was seen between H. pylori and degree of fibrosis. P<0.0001, High statistical significance was seen between H. pylori and degree of hyperplasia. P<0.003.
Conclusions: There is no significant positive corelation between H. pylori infection and Calculous Cholecystitis H. pylori infection is associated with high degree of hyperplasia, degree of fibrosis and Inflammatory mononuclear infiltrate of Gall bladder.
