Clinicopathological study of pineal gland lesions
Author(s): Dr. Mohammed Sikandar and Dr. M Srinivas Reddy
Abstract: Background: Pineal parenchymal tumors are the second most common form of pineal tumor.Aims: To study the incidence, age distribution, gender distribution of pineal region tumors and post-operative outcome.Materials and Methods: The present study is a prospective study comprising 20 cases of Pineal Region tumors, studied over a two and half year period. Data related to all cases were retrieved from archives. Available clinical data including, patient age, sex, clinical features, Imaging and surgical findings, tumor histology, outcome were also received from the Department of Neurosurgery Medical record Department. All pineal region tumors received at Neurosurgery department with adequate pre-operative; intra-operative and postoperative information were included in the study. Pineal region tumors comprising the Pineal parenchymal cell tumors, Germ cell tumors, Glial cell tumors, and other miscellaneous tumors and cysts.Results: Most common age group for the pineal region tumors is second and third decade and the Male to Female ratio is 1:1. Malignant nature of pineal region tumors is 17 cases incidence being 85%. Predominant grade of the pineal region tumors are grade I tumors commonest presenting symptoms being headache and vomiting. Commonest clinical sign is papilledema of features suggestive raised intracranial pressure. Most of patients presented at delayed stage with large tumor and morbid state with hydrocephalus, majority of the patients underwent shunt surgery before definitive surgery, some patients underwent external ventricular drainage simultaneously after surgery. No surgical mortality, one patient detoriated after third post operative day did not recovered and died. Inpatient had developed meningitis, sepsis didn't recover and died. Mortality 2 cases. Medium follow up period is one year. Three cases followed recurrent symptoms advised radiotherapy. Two cases came with shunt malfunction. Conclusion: Many of the approaches are interchangeable and they are depending on anatomical location and surgeon s choice and experience.