Abstract: Introduction: Surgical site infection (SSI) is one of the most common cause of post-operative morbidity. The introduction of antibiotics in 20th century leads to great improvement in surgical outcomes. But with rampant antibiotic use sets its own problems like rise in incidence of antibiotic resistant strains like (MRSA) and rise in incidence of allergies and other complications of antibiotic use
Aims and Objectives: To compare the efficacy of single dose prophylactic antibiotic versus Empirical post-operative antibiotic prophylaxis in prevention of SSI
Materials and Methods: The present study was a comparative study of patients receiving single dose prophylactic antibiotic versus empirical post-operative antibiotic prophylaxis in prevention of SSI during 2 years study period, Patents who met the inclusion criteria were included in the study
Results: This study includes 100 clean and clean contaminated cases randomised in to two groups of 50 each. The study group will receive a single dose antibiotic pre-operatively while the control group will receive 3 to 5 days empirical antibiotic therapy. The common age group was 30-50 years; there is no significant difference between the control group and study group based on age. In this study there is no significant difference in post-operative fever in both study and control groups and there is significant difference in postoperative swelling due to SSI between this two groups with p-value of 0.6.
Conclusion: Based on my study I would like to conclude that it is recommendable to use single dose antibiotic prophylaxis using appropriate antibiotics for all class 1 and class 2 cases, as per the study results there is no significant difference in incidence of SSI when compared to the traditional regimens with the added advantage of significant reduction in both hospital stay with resultant savings in resources.
