Vol. 8, Issue 3, Part B (2024)

Abstract: Nephrolithiasis is a long-standing medical condition, although the precise processes behind the production and progression of kidney stones remain mainly elusive. In recent years, advancements in technology have led to the development and implementation of several theories and tactics for surgically managing kidney stones. Authors and other research groups have observed that there are five distinct mechanisms responsible for the production of kidney stones. Urinary super saturation and crystallization are the main factors that cause crystals to form within the kidneys. Randall's plaques are acknowledged as the source of calcium oxalate stone development. Sex hormones are likely to have a crucial role in the development of nephrolithiasis and could therefore be potential targets for novel medications aimed at inhibiting the formation of kidney stones. The microbiome, which consists of bacteria that produce urease, nano-bacteria, and intestinal microbiota, is expected to significantly impact urological health in both beneficial and detrimental ways due to its metabolic output and other contributions. Finally, the immunological response, specifically the development of macrophages, plays a vital role in the creation of calcium oxalate crystals in the kidneys. The current understanding of each of these five components of kidney stone production is examined in this study. This knowledge can be utilized to investigate new study prospects and enhance the comprehension of the onset and progression of kidney stones for urologists, nephrologists, and primary care practitioners.