Vol. 9, Issue 1, Part B (2025)

Background: Common consequences are surgical site infections. Due to topical and systemic antibiotic resistance, antiseptics were used to prevent wound infections. Povidone-iodine killed germs quickly. The aim of study is to compare the effect and safety of povidone iodine 3% and 10% on post-operative infection rates. 
Method: A convenient sample of 150 open appendectomy patients in a cross-sectional prospective research. Patients who met qualifying requirements were assigned to three equal-numbered groups. Group 1: controls, Group 2: 10% Povidone Iodine, and Group 3: 3%. Group associations were assessed using analysis of variance and Chi-square test. Significant P values are 0.05 or less. 
Results: The sample had an average age of 29.5±6.8 years. Only 14 (9.3%) of 150 individuals suffered surgical site infections. Five (10%), one (2%), and three (6%) of group1, group2, and group3 patients had superficial infection. Deep infection was detected in 4 (8%) group1 patients and 1 (2%) group3 patient. One surgical site infection occurred in group2, compared to nine in controls and four in group3. No significant connection was found between age, gender, BMI, chronic diseases, study duration, incision length, and SSI infections among the groups (P>0.05). Staphylococci were the most common infection at 8 (57.1%), followed by E. coli 4 (28.6%), Klebsiella 1 (7.1%), and Candida 1 (7.1%). 
Conclusions: The study concluded a safe and possible application of povidone iodine 10% irrigation pre wound closure with low infection rate.