Vol. 10, Issue 1, Part A (2026)

Molecular subtypes and organ-specific metastatic patterns in breast cancer: A cross-sectional study at a tertiary referral hospital in West Sumatra

Author(s):

Widya Zulma, Daan Khambri and Rony Rustam

Abstract:

Background: Breast cancer heterogeneity significantly influences the site of distant recurrence. This study aims to analyze the correlation between molecular subtypes and organ-specific metastasis in a major referral center in Indonesia.

Methods: A cross-sectional study was conducted on 96 metastatic breast cancer patients at Dr. M. Djamil Hospital (2023-2025). Molecular subtypes (Luminal A, Luminal B, HER2-enriched, TNBC) and metastatic sites (bone, lung, liver, brain) were analyzed using Chi-square tests.

Results: The HER2-enriched subtype was most frequent (36.5%). Luminal A was strongly associated with bone metastasis (83.3%), while HER2-enriched and Luminal B predominantly spread to the lungs. A significant association (p=0.000) was found between subtype and metastatic site.

Conclusion: Molecular subtypes are predictive of metastatic organotropism, allowing for more targeted clinical surveillance.

DOI: https://doi.org/10.33545/surgery.2026.v10.i1.A.1269

Pages: 12-13  |  96 Views  51 Downloads

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How to cite this article:
Widya Zulma, Daan Khambri and Rony Rustam. Molecular subtypes and organ-specific metastatic patterns in breast cancer: A cross-sectional study at a tertiary referral hospital in West Sumatra. Int. J. Surg. Sci. 2026;10(1):12-13. DOI: https://doi.org/10.33545/surgery.2026.v10.i1.A.1269